Tirzepatide

2 days agoan exploratory analysis of data from the surpass-4 trial has shown that adults with type 2 diabetes and increased cardiovascular risk receiving tirzepatide experience fewer renal complications. A drug approved to treat diabetes allowed patients without the disease to drop up to 21 percent of their body weight according to a new study.

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GLP-1 and GIP are gut hormones.

. Early phase trials in T2DM indicate that tirzepatide improves clinical outcomes beyond those achieved by a selective GLP-1 receptor agonist. It is a dual glucose-dependent insulinotropic polypeptide GIP and GLP-1 receptor agonist. Tirzepatide is a novel once-weekly injectable glucose-dependent insulinotropic polypeptide GIP and glucagon-like peptide-1 GLP-1 receptor agonist that integrates the actions of the GIP and GLP-1 incretins into a single molecule representing a new class of medicines for the treatment of type 2 diabetes.

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide GIP and GLP-1 agonist that has been studied recently as a treatment for patients with noncirrhotic NASH SYNERGY-NASH NCT04166773 given its association with significant weight loss and improvement in features of metabolic syndrome in diabetes trials Frias et al 2018 2020. First the highest tested dosage of tirzepatide 15 mgweek over 72 weeks produced a 5 or greater loss in baseline weight in 91-96 of patients an effect not previously seen in any prior. Tirzepatide is the first drug in a new class of diabetes medications.

Ania Jastreboff of the Yale University School of Medicine and colleagues presented new data at the ADA 82nd Scientific Sessions in New Orleans Louisiana on the SURMOUNT-1 trial which investigated the effectiveness of tirzepatide a drug recently approved as Mounjaro by the FDA for treating type 2 diabetes for the treatment of obesity. Tirzepatide is a linear polypeptide of 39 amino acids which has been chemically modified by lipidation to improve its uptake into cells and its stability to metabolism. Tirzepatide is an analogue of gastric inhibitory polypeptide GIP a human hormone which stimulates the release of insulin from the pancreas.

USA Today reports the promising results suggest that. 1 day agoTirzepatide is the first drug in a new family of medicines that target two hormones glucagon-like peptide-1 GLP-1 and glucose-dependent insulinotropic polypeptide GIP that are involved in. Tirzepatide LY3298176 is a dual GIP and GLP-1 receptor agonist under development for the treatment of type 2 diabetes mellitus T2DM obesity and nonalcoholic steatohepatitis.

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